Bottom Line: Quetiapine's low risk for EPS and broad spectrum of efficacy make it an appealing first-choice agent. However, sedation, weight gain, and orthostasis may limit use. Dosing at bedtime, or switching to XR, may help reduce daytime sedation. The information below is derived from a clinical trial database for SEROQUEL XR consisting of approximately 3400 patients exposed to SEROQUEL XR for the treatment of Schizophrenia, Bipolar Disorder, and Major Depressive Disorder in placebo-controlled trials. SEROQUEL XR is a once-daily tablet approved in adults for add-on treatment to antidepressants for patients with major depressive disorder (MDD) who did not have an adequate response to antidepressant therapy; Find patient medical information for Quetiapine (Seroquel) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings Both formulations are effective treatment options with similar overall efficacy profiles, but the XR formulation offers the convenience of once-daily dosing which may significantly improve medication adherence in many patients. SEROQUEL XR is indicated for the acute treatment of manic or mixed episodes associated with bipolar I disorder, both as monotherapy and as an adjunct to lithium or divalproex. Medscape - Schizophrenia, bipolar disorder-specific dosing for Seroquel, Seroquel XR (quetiapine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &. Seroquel XR is used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel XR is used alone or in combination with divalproex or lithium to treat manic episodes in adults with bipolar disorder. Seroquel XR is a prescription medicine used to treat the symptoms of Schizophrenia and Bipolar Disorder, for maintenance, mania and depressive episodes and Major Depressive Disorder. Seroquel XR may be used alone or with other medications. Seroquel XR belongs to a class of drugs called Antipsychotics, 2nd Generation; Antimanic Agents. Seroquel (quetiapine) has been used at low doses to help with sleep, but studies are lacking and serious side effects can occur. Many doctors do not recommend Seroquel as a sleep aid in the general population, or may only prescribe it for people with certain mental health mood or psychosis disorders.