SEROQUEL XR is a once-daily tablet approved in adults for add-on treatment to antidepressants for patients with major depressive disorder (MDD) who did not have an adequate response to antidepressant therapy; Find patient medical information for Quetiapine (Seroquel) on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings The information below is derived from a clinical trial database for SEROQUEL XR consisting of approximately 3400 patients exposed to SEROQUEL XR for the treatment of Schizophrenia, Bipolar Disorder, and Major Depressive Disorder in placebo-controlled trials. Seroquel extended release is used in combination with antidepressant medications to treat major depressive disorder in adults. Seroquel tablets may be used as part of a treatment program to treat bipolar disorder and schizophrenia in children and teenagers. Seroquel XR is used to treat schizophrenia in adults and children who are at least 13 years old. Seroquel XR is used alone or in combination with divalproex or lithium to treat manic episodes in adults with bipolar disorder. Quetiapine is used alone or together with other medicines to treat bipolar disorder (depressive and manic episodes) and schizophrenia. Quetiapine extended-release tablet is also used together with other antidepressants to treat major depressive disorder. Seroquel XR is a prescription medicine used to treat the symptoms of Schizophrenia and Bipolar Disorder, for maintenance, mania and depressive episodes and Major Depressive Disorder. Seroquel XR may be used alone or with other medications. Seroquel XR belongs to a class of drugs called Antipsychotics, 2nd Generation; Antimanic Agents. Quetiapine is one of only two antipsychotics (the other is cariprazine) that produce equal efficacy as standalone therapies for mixed manic-depressive mood swings as they do in combination with an SSRI antidepressant. SEROQUEL XR is indicated for the treatment of schizophrenia. The efficacy of SEROQUEL XR in schizophrenia was established in one 6-week and one maintenance trial in adults with schizophrenia. Medscape - Schizophrenia, bipolar disorder-specific dosing for Seroquel, Seroquel XR (quetiapine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy &.